Method to recover a lipophilic drug from hydroxypropyl methylcellulose matrix tablets
نویسندگان
چکیده
منابع مشابه
Colon Specific Drug Delivery: Effect of Eudragit Enteric Coating on Hydroxypropyl Methylcellulose Matrix Tablets of Flurbiprofen
Objective: The present research is focused on developing flurbiprofen colon-specific tablets based on timed release and pH-sensitivity. Methods and Material: This study is designed to study the effect of eudragit coating on the drug release from hydroxypropyl methylcellulose matrix to achieve the colon-specific release. Hydroxypropyl methylcellulose matrix tablets were prepared by wet granulati...
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A novel mathematical model for the water transport into and drug release from hydroxypropyl methylcellulose (HPMC) tablets is presented. Fick's second law of diffusion is used to describe the mass transfer processes in the three-component system drug/polymer/water. Numerical solutions of the respective set of partial differential equations are provided, considering axial and radial diffusion wi...
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Hydroxy propyl methyl cellulose can be used in the development of different drug delivery technology. Nowadays it is a widely used polymer and different viscosity grade of this polymer is available. The hydrophilic and hydrophobic form (both variants) of this polymer is also available. This study includes a review of this polymer on use in different drug delivery system mosty focusing on more r...
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Extended release formulation of alfuzosin, an a-antagonist used for prostatic hypertrophy, is available in market. It is convenient for older patients to take only one tablet a day. Marketed alfuzosin formulation is three layered geomatrix tablet that requires special facilities, high cost, more time and complex operation than normal direct compression formulation. Therefore, a less compl...
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Hydrophilic matrix tablets (matrices) for oral use are designed to hydrate on swallowing, and form a ‘gel’ layer of hydrated polymer at the tablet surface to control the rate of drug release during passage of the matrix through the gastrointestinal tract. During gastrointestinal transit, the matrices are reduced in size through surface erosion and dissolution. This reduces the probability of ex...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2001
ISSN: 1530-9932
DOI: 10.1208/pt020208